Private Practice Infectious Disease

(ISSN: 2770-4629) Open Access Journal
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PPID 2022, 2(1), 7; doi: 10.55636/ppid2010007

A Case Report of Culture-Negative Burkholderia Prosthetic Valve Endocarditis Identified by Metagenomic Next-Generation Sequencing (mNGS)

1 Department of Internal Medicine at Advocate Lutheran General Hospital (ALGH), 1775 Dempster Street, Park Ridge, IL 60068, USA
2 Metro Infectious Disease Consultants
* Corresponding author: ; Tel.: +1-(708)-955-2425
* Author to whom correspondence should be addressed.
Received: 10 May 2022 / Revised: 11 Jun 2022 / Accepted: 16 Jun 2022 / Published: 30 Jun 2022
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Abstract

Burkholderia cepacia complex is a group of closely related opportunistic Gram-negative species that can be found in soil and water. Burkholderia cepacia complex is commonly associated with pulmonary infections in patients with cystic fibrosis, hospital-borne outbreaks related to contaminated medicines and devices, and, rarely, prosthetic valve endocarditis. The treatment of Burkholderia cepacia remains challenging because of the organism’s intrinsic resistance to several antibiotics, and often requires combination therapy. Through this clinical vignette, we review an interesting case of culture-negative Burkholderia prosthetic valve endocarditis identified through metagenomic next-generation sequencing (mNGS) and the challenges associated with the diagnosis and selection of an appropriate treatment.
Keywords: endocarditis; culture-negative; prosthetic valve; Burkholderia cepacian; metagenomic next-generation sequencing; Karius
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
CITE
Moy, L.N.; Han, A. A Case Report of Culture-Negative Burkholderia Prosthetic Valve Endocarditis Identified by Metagenomic Next-Generation Sequencing (mNGS). private_pract_infectious_disease 2022, 2, 7.
Moy LN, Han A. A Case Report of Culture-Negative Burkholderia Prosthetic Valve Endocarditis Identified by Metagenomic Next-Generation Sequencing (mNGS). Private Practice Infectious Disease. 2022; 2(1):7.
Moy, Lindsay N.; Han, Alice. 2022. "A Case Report of Culture-Negative Burkholderia Prosthetic Valve Endocarditis Identified by Metagenomic Next-Generation Sequencing (mNGS)." private_pract_infectious_disease 2, no. 1: 7.
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